CNGA1 Back

cyclic nucleotide gated channel alpha 1

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NCBI Description of CNGA1
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CNGA1 Add / Edit CNGA1: Annotations

No community annotations yet for CNGA1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CNGA1 is highly significantly mutated in
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CNGA1 is significantly mutated in
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CNGA1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CNGA1