CNBP Back

CCHC-type zinc finger, nucleic acid binding protein

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NCBI Description of CNBP

This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CNBP Add / Edit CNBP: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CNBP is highly significantly mutated in
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CNBP is significantly mutated in
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CNBP is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CNBP