CMBL Back

carboxymethylenebutenolidase homolog (Pseudomonas)

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NCBI Description of CMBL
CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010].

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CMBL is highly significantly mutated in
(none)
CMBL is significantly mutated in
(none)
CMBL is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CMBL