CLTA Back

clathrin, light chain (Lca)

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NCBI Description of CLTA
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12.

Community Annotation of CLTA Add / Edit CLTA: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CLTA is highly significantly mutated in
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CLTA is significantly mutated in
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CLTA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CLTA