CLIC1 Back

chloride intracellular channel 1

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NCBI Description of CLIC1

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CLIC1 is highly significantly mutated in
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CLIC1 is significantly mutated in
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CLIC1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CLIC1