C-type lectin domain family 4, member E

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CLEC4E

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Community Annotation of CLEC4E Add / Edit CLEC4E: Annotations

No community annotations yet for CLEC4E.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CLEC4E is highly significantly mutated in
CLEC4E is significantly mutated in
CLEC4E is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CLEC4E