CLDN4 Back

claudin 4

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NCBI Description of CLDN4
This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

Community Annotation of CLDN4 Add / Edit CLDN4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CLDN4 is highly significantly mutated in
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CLDN4 is significantly mutated in
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CLDN4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CLDN4