CLDN25 Back

claudin 25

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NCBI Description of CLDN25

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Sequence Note: This RefSeq record was created from genomic sequence data because no transcript was available for the gene. The extent of this transcript is supported by orthologous data.

Community Annotation of CLDN25 Add / Edit CLDN25: Annotations

No community annotations yet for CLDN25.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CLDN25 is highly significantly mutated in
CLDN25 is significantly mutated in
CLDN25 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CLDN25