CLDN23 Back

claudin 23

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NCBI Description of CLDN23
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer.

Community Annotation of CLDN23 Add / Edit CLDN23: Annotations

No community annotations yet for CLDN23.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CLDN23 is highly significantly mutated in
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CLDN23 is significantly mutated in
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CLDN23 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CLDN23