CLDN22 Back

claudin 22

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NCBI Description of CLDN22

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand.

Community Annotation of CLDN22 Add / Edit CLDN22: Annotations

No community annotations yet for CLDN22.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CLDN22 is highly significantly mutated in
CLDN22 is significantly mutated in
CLDN22 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CLDN22