CLDN2 Back

claudin 2

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NCBI Description of CLDN2

This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.

Community Annotation of CLDN2 Add / Edit CLDN2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CLDN2 is highly significantly mutated in
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CLDN2 is significantly mutated in
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CLDN2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CLDN2