CLDN15 Back

claudin 15

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NCBI Description of CLDN15
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Community Annotation of CLDN15 Add / Edit CLDN15: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CLDN15 is highly significantly mutated in
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CLDN15 is significantly mutated in
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CLDN15 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CLDN15