CLDN10 Back

claudin 10

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NCBI Description of CLDN10
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.

Community Annotation of CLDN10 Add / Edit CLDN10: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CLDN10 is highly significantly mutated in
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CLDN10 is significantly mutated in
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CLDN10 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CLDN10