CLCA1 Back

chloride channel, calcium activated, family member 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CLCA1
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.

Community Annotation of CLCA1 Add / Edit CLCA1: Annotations

No community annotations yet for CLCA1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CLCA1 is highly significantly mutated in
(none)
CLCA1 is significantly mutated in
(none)
CLCA1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CLCA1