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citron (rho-interacting, serine/threonine kinase 21)

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NCBI Description of CIT
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.

Community Annotation of CIT Add / Edit CIT: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CIT is highly significantly mutated in
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CIT is significantly mutated in
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CIT is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CIT