CIDEA Back

cell death-inducing DFFA-like effector a

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CIDEA
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.

Community Annotation of CIDEA Add / Edit CIDEA: Annotations

No community annotations yet for CIDEA.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CIDEA is highly significantly mutated in
(none)
CIDEA is significantly mutated in
(none)
CIDEA is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CIDEA