CHTF8 Back

CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)

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NCBI Description of CHTF8
This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternatively spliced transcript variants have been described. This gene has a pseudogene on chromosome X.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHTF8 is highly significantly mutated in
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CHTF8 is significantly mutated in
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CHTF8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CHTF8