CHSY1 Back

chondroitin sulfate synthase 1

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NCBI Description of CHSY1
This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome.

Community Annotation of CHSY1 Add / Edit CHSY1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHSY1 is highly significantly mutated in
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CHSY1 is significantly mutated in
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CHSY1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CHSY1