CHST8 Back

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8

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NCBI Description of CHST8
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene.

Community Annotation of CHST8 Add / Edit CHST8: Annotations

No community annotations yet for CHST8.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHST8 is highly significantly mutated in
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CHST8 is significantly mutated in
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CHST8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CHST8