CHRNB2 Back

cholinergic receptor, nicotinic, beta 2 (neuronal)

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NCBI Description of CHRNB2
Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHRNB2 is highly significantly mutated in
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CHRNB2 is significantly mutated in
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CHRNB2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CHRNB2