CHRNA3 Back

cholinergic receptor, nicotinic, alpha 3

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NCBI Description of CHRNA3
This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.

Community Annotation of CHRNA3 Add / Edit CHRNA3: Annotations

No community annotations yet for CHRNA3.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHRNA3 is highly significantly mutated in
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CHRNA3 is significantly mutated in
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CHRNA3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CHRNA3