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NCBI Description of CHRD

This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequence has not been determined.

Community Annotation of CHRD Add / Edit CHRD: Annotations

No community annotations yet for CHRD.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CHRD is highly significantly mutated in
CHRD is significantly mutated in
CHRD is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CHRD