CHN1 Back

chimerin (chimaerin) 1

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NCBI Description of CHN1
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Community Annotation of CHN1 Add / Edit CHN1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHN1 is highly significantly mutated in
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CHN1 is significantly mutated in
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CHN1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CHN1