CHMP4A Back

chromatin modifying protein 4A

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NCBI Description of CHMP4A
CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008].

Community Annotation of CHMP4A Add / Edit CHMP4A: Annotations

No community annotations yet for CHMP4A.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHMP4A is highly significantly mutated in
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CHMP4A is significantly mutated in
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CHMP4A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CHMP4A