CHI3L1 Back

chitinase 3-like 1 (cartilage glycoprotein-39)

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NCBI Description of CHI3L1
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHI3L1 is highly significantly mutated in
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CHI3L1 is significantly mutated in
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CHI3L1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CHI3L1