CHEK1 Back

CHK1 checkpoint homolog (S. pombe)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CHEK1

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Community Annotation of CHEK1 Add / Edit CHEK1: Annotations

No community annotations yet for CHEK1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHEK1 is highly significantly mutated in
(none)
CHEK1 is significantly mutated in
(none)
CHEK1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CHEK1