CHD3 Back

chromodomain helicase DNA binding protein 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CHD3

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Community Annotation of CHD3 Add / Edit CHD3: Annotations

No community annotations yet for CHD3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHD3 is highly significantly mutated in
(none)
CHD3 is significantly mutated in
(none)
CHD3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CHD3