CHD2 Back

chromodomain helicase DNA binding protein 2

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NCBI Description of CHD2
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Community Annotation of CHD2 Add / Edit CHD2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHD2 is highly significantly mutated in
CHD2 is significantly mutated in
CHD2 is near significance in
Chronic lymphocytic leukemia
CLL
5 patients (3%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CHD2