CHAF1B Back

chromatin assembly factor 1, subunit B (p60)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CHAF1B
Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.

Community Annotation of CHAF1B Add / Edit CHAF1B: Annotations

No community annotations yet for CHAF1B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHAF1B is highly significantly mutated in
(none)
CHAF1B is significantly mutated in
(none)
CHAF1B is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CHAF1B