CASP8 and FADD-like apoptosis regulator

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CFLAR

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.

Community Annotation of CFLAR Add / Edit CFLAR: Annotations

No community annotations yet for CFLAR.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CFLAR is highly significantly mutated in
CFLAR is significantly mutated in
CFLAR is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CFLAR