CFLAR Back

CASP8 and FADD-like apoptosis regulator

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NCBI Description of CFLAR
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.

Community Annotation of CFLAR Add / Edit CFLAR: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CFLAR is highly significantly mutated in
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CFLAR is significantly mutated in
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CFLAR is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CFLAR