CFL2 Back

cofilin 2 (muscle)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CFL2
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.

Community Annotation of CFL2 Add / Edit CFL2: Annotations

No community annotations yet for CFL2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CFL2 is highly significantly mutated in
(none)
CFL2 is significantly mutated in
(none)
CFL2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CFL2