CFHR1 Back

complement factor H-related 1

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NCBI Description of CFHR1
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.

Community Annotation of CFHR1 Add / Edit CFHR1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CFHR1 is highly significantly mutated in
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CFHR1 is significantly mutated in
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CFHR1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CFHR1