CES1 Back

carboxylesterase 1 (monocyte/macrophage serine esterase 1)

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NCBI Description of CES1
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.

Community Annotation of CES1 Add / Edit CES1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CES1 is highly significantly mutated in
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CES1 is significantly mutated in
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CES1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CES1