centromere protein E, 312kDa

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NCBI Description of CENPE

Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.

Community Annotation of CENPE Add / Edit CENPE: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CENPE is highly significantly mutated in
CENPE is significantly mutated in
CENPE is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CENPE