CELSR2 Back

cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CELSR2
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments.

Community Annotation of CELSR2 Add / Edit CELSR2: Annotations

No community annotations yet for CELSR2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CELSR2 is highly significantly mutated in
(none)
CELSR2 is significantly mutated in
(none)
CELSR2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CELSR2