CELA2A Back

chymotrypsin-like elastase family, member 2A

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NCBI Description of CELA2A
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CELA2A is highly significantly mutated in
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CELA2A is significantly mutated in
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CELA2A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CELA2A