CEL Back

carboxyl ester lipase (bile salt-stimulated lipase)

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NCBI Description of CEL

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. Sequence Note: The 3' terminal exon of this RefSeq is inferred based on aligning transcripts.

Community Annotation of CEL Add / Edit CEL: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CEL is highly significantly mutated in
CEL is significantly mutated in
CEL is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CEL