CEBPB Back

CCAAT/enhancer binding protein (C/EBP), beta

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CEBPB
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.

Community Annotation of CEBPB Add / Edit CEBPB: Annotations

No community annotations yet for CEBPB.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CEBPB is highly significantly mutated in
(none)
CEBPB is significantly mutated in
(none)
CEBPB is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CEBPB