CDT1 Back

chromatin licensing and DNA replication factor 1

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NCBI Description of CDT1
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDT1 is highly significantly mutated in
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CDT1 is significantly mutated in
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CDT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDT1