CDKN3 Back

cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CDKN3

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CDKN3 Add / Edit CDKN3: Annotations

No community annotations yet for CDKN3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CDKN3 is highly significantly mutated in
CDKN3 is significantly mutated in
CDKN3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CDKN3