CDKN3 Back

cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)

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NCBI Description of CDKN3
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CDKN3 Add / Edit CDKN3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDKN3 is highly significantly mutated in
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CDKN3 is significantly mutated in
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CDKN3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDKN3