CDKN2B Back

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

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NCBI Description of CDKN2B

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Community Annotation of CDKN2B Add / Edit CDKN2B: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDKN2B is highly significantly mutated in
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CDKN2B is significantly mutated in
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CDKN2B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CDKN2B