CDKN1C Back

cyclin-dependent kinase inhibitor 1C (p57, Kip2)

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NCBI Description of CDKN1C
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDKN1C is highly significantly mutated in
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CDKN1C is significantly mutated in
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CDKN1C is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDKN1C