CDKL5 Back

cyclin-dependent kinase-like 5

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NCBI Description of CDKL5
This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDKL5 is highly significantly mutated in
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CDKL5 is significantly mutated in
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CDKL5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDKL5