CDK5RAP2 Back

CDK5 regulatory subunit associated protein 2

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NCBI Description of CDK5RAP2
This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants.

Community Annotation of CDK5RAP2 Add / Edit CDK5RAP2: Annotations

No community annotations yet for CDK5RAP2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDK5RAP2 is highly significantly mutated in
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CDK5RAP2 is significantly mutated in
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CDK5RAP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDK5RAP2