CDK2 Back

cyclin-dependent kinase 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CDK2

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.

Community Annotation of CDK2 Add / Edit CDK2: Annotations

No community annotations yet for CDK2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDK2 is highly significantly mutated in
(none)
CDK2 is significantly mutated in
(none)
CDK2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CDK2