CDH5 Back

cadherin 5, type 2, VE-cadherin (vascular epithelium)

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NCBI Description of CDH5
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.

Community Annotation of CDH5 Add / Edit CDH5: Annotations

No community annotations yet for CDH5.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDH5 is highly significantly mutated in
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CDH5 is significantly mutated in
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CDH5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDH5