CDH2 Back

cadherin 2, type 1, N-cadherin (neuronal)

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NCBI Description of CDH2
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

Community Annotation of CDH2 Add / Edit CDH2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDH2 is highly significantly mutated in
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CDH2 is significantly mutated in
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CDH2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDH2