CDH15 Back

cadherin 15, M-cadherin (myotubule)

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NCBI Description of CDH15
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.

Community Annotation of CDH15 Add / Edit CDH15: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDH15 is highly significantly mutated in
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CDH15 is significantly mutated in
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CDH15 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDH15