CDC73 Back

cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

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NCBI Description of CDC73
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of CDC73 Add / Edit CDC73: Annotations

No community annotations yet for CDC73.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDC73 is highly significantly mutated in
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CDC73 is significantly mutated in
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CDC73 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDC73