CDC42EP3 Back

CDC42 effector protein (Rho GTPase binding) 3

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NCBI Description of CDC42EP3
This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants.

Community Annotation of CDC42EP3 Add / Edit CDC42EP3: Annotations

No community annotations yet for CDC42EP3.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDC42EP3 is highly significantly mutated in
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CDC42EP3 is significantly mutated in
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CDC42EP3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDC42EP3